The Ssese Islands are an archipelago of eighty-four islands in the northwestern part of Lake Victoria in Uganda. The islands are coterminous with the Kalangala District in southern Central Uganda, which does not have any territory on mainland Uganda.

The islands occupy the northwestern corner of Lake Victoria, the second-largest freshwater lake in the world. The largest island in the archpelag is called Bugala Island. Its largest town, called Kalangala serves as the headquarters of the district that carries the same name (Kalangala District). Kalangala is located located approximately 51 kilometres (32 mi), across water, southwest of Entebbe, in Wakiso District, on the Ugandan mainland.

The islands lie in two main groups. The south west can be referred to as the Bugala Group group, after Bugala Island, the largest in the archipelago. The northeastern group can be referred to as the Koome Group, after Koome Island, the largest in that group. The two groups are separated by the Koome Channel.

Other inslands in the Bugala Group include: Bubeke, Bufumira, Bugaba, Bukasa, Buyova, Funve and Serinya. The main islands in the Koome Group include: Damba, Koome and Luwaji.

The Ssese Islands are inhabited by the Bantu speaking Bassese tribe, closely related to the Baganda and the Basoga, and speaking a similar, though distinct language. Prior to the arrival of Europeans, the islands were one of the most important spiritual centers of the region. About forty-three (50%) of the islands are inhabited. The islands vary in size from less than 10,000 square metres (2.5 acres), to over 40 kilometres (25 mi) in length for the largest island, Bugala Island.